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[h3]Stem Cell[/h3]
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[callout1]Stem Cell Therapy for Heart Failure[/callout1]
What is Heart Failure?
Heart failure is a condition in which the heart is not able to pump enough blood through the body to maintain normal function. The cause of this can be either functional or structural disorder of the heart. Common causes of heart failure include cardiomyopathy, hypertension, heart valve problems, and coronary artery disease. There is no present cure for heart failure.
Can stem cells help treat heart failure?
CD 34+ stem cells have the ability to not only home into the damaged areas but also to trigger a series of very beneficial biological events which culminate in healing of the heart muscle. For example, animal studies have demonstrated that stem cell therapy will cause new muscle cells to be formed through stimulation of dormant stem cells that are already inside the heart muscle. In these studies, the administered stem cell also transformed into new heart muscle cells. Our technology allows you own body to release large volumes (up to eight times your present level) of CD 34+ stem cells.
Which kinds of stem cells are used to treat heart disease and where do they come from?
The CD 34+ stem cells are ideally suited for the treatment of heart failure. HBOT exposure causes the bone marrow to mobilize cascades of CD 34+ stem cells from the patient’s own body. Naturally, these cells are keyed with the patient’s own DNA, therefore these stem cells pose no rejection risk because the body does not recognize them as foreign.
We offer two protocols to mobilize the CD 34+ stem cells:
- Two 60-minute hyperbaric exposures daily for 20 consecutive days (each exposure is for approximately 75-minutes in total duration)
- One 90-minute hyperbaric exposure daily for 10 consecutive days (each exposure is approximately 2- hours in total duration)
It is suggested that the patient/caregiver read the University of Pennsylvania School of Medicine “Stem Cell Mobilization Study”. Please click here for copy of full study to understand how Hyperbaric Oxygen Therapy (HBOT) has been proven to mobilize CD 34+ stem cells after 40 cumulative hours of exposure.
The University of Texas School of Medicine is using stem cell technology to grow new heart valves in the lab.
The following extract from a scientific study shows that adult (age appropriate) stem cells are able to offer great hope for patients who present with heart disease.
When we tried to tell the University of Texas Stem Cell Unit (working on growing new heart valves with CD 34+ adult stem cells) about the proven fact that HBOT increases the amount of CD34+ stem cells (keyed with your own DNA) by a factor of 800% they hung up on us!
Clearly, this discovery would have caused them to loose their funding, so they continue to try to find ways to mobilize more stem cells with drugs and undesirable side affects.
Researchers have demonstrated for the first time that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart failure.
Using an animal model, the researchers showed that this non-invasive procedure increased myocytes, or heart cells, by two-fold and reduced cardiac tissue injury by 60 percent.
The therapy also improved function of the left ventricle, the primary pumping chamber of the heart, by 40 percent and reduced fibrosis, the hardening of the heart lining that impairs its ability to contract, by up to 50 percent.
“This work demonstrates a novel non-invasive mesenchymal stem cell therapeutic regimen for heart failure based on an intramuscular delivery route,” said Techung Lee, senior author on the paper.
Mesenchymal stem cells are found in the bone marrow and can differentiate into a variety of cell types.
“Injecting mesenchymal stem cells or factors released by mesenchymal stem cells improved ventricular function, promoted myocardial regeneration, lessened apoptosis (cell death) and fibrotic remodeling, recruited bone marrow progenitor cells and induced myocardial expression of multiple growth factor genes,” Lee said.
“These findings highlight the critical ‘cross-talks’ between the injected mesenchymal stem cells and host tissues, culminating in effective cardiac repair for the failing heart.”
The heart disease death rate has dropped significantly in the last three decades due to better treatments, resulting in large numbers of people living with heart failure. This advance has lead to another health hurdle: The only therapy available to reverse the decline in cardiac function is heart transplantation, and donor hearts are very scarce.
Clinical trials of myocardial stem cell therapy traditionally have relied on surgery, infusing the stem cells directly into the heart or injecting them into the myocardium, the heart muscle, invasive methods that can result in harmful scar tissue, arrhythmia, calcification or small vessel blockages.
“In our research with a swine model of heart failure,” said Lee, “we’ve found that only 1-to-2 percent of mesenchymal stem cells infused into the myocardium grafted into the heart, and there was no evidence that they differentiated into heart muscle cells. In addition, diseased tissue is not a healthy environment for cell growth.
“For these reasons, and because patients with heart failure are not good surgical risks, it made sense to explore a non-invasive cell delivery approach,” said Lee. “An important feature of mesenchymal stem cells is their ability to produce a plethora of tissue healing effects, known as “trophic factors,” which can be harnessed for stem cell therapy for heart failure.
Lee noted that the multiple trophic factors produced by mesenchymal stem cells have been shown in the literature to be capable of reducing tissue injury, inhibiting fibrosis, promoting angiogenesis, stimulating recruitment and proliferation of tissue stem cells, and reducing inflammatory oxidative stress, a common cause of cardiovascular disease and heart failure.
“Since skeletal muscle is the most abundant tissue in the body and can withstand repeated injection of large number of stem cells, we thought it would be a good method to deliver mesenchymal stem cells,” Lee said. “We hypothesized that mesenchymal stem cells, via secretion of these functionally synergistic trophic factors, would be able to rescue the failing heart even when delivered away from the myocardium.
“This study proves our hypothesis,” said Lee. “We’ve demonstrated that injecting mesenchymal stem cells, or trophic factors released by mesenchymal stem cells, into skeletal muscle improved ventricular function, promoted regeneration of heart tissue, decreased cell death and improved other factors that cause heart failure.
“This non-invasive stem cell administration regimen, if validated clinically, is expected to facilitate future stem cell therapy for heart failure.”
Lee said the next step is to use genetic and pharmacological engineering to make the stem cells more active, so good therapeutic effects can be achieved with fewer cells.
“That is our goal. It would reduce the cost of stem cell therapy and make it more affordable for patients in the future.”
References:
1. Techung Lee, et al. Heart Failure Therapy Mediated by the Trophic Activities of Bone Marrow Mesenchymal Stem Cells: A Non-invasive Therapeutic Regimen. Am J Physiol Heart Circ Physiol (April 24, 2009). doi:10.1152/ajpheart.00186.2009.
2. University of Pennsylvania School of Medicine “Stem Cell Mobilization Study”..
Stem Cell Therapy for Heart Failure
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We really enjoyed meeting you and getting to know you over the last 3 weeks. Your sweet demeanor and hospitality made us feel right at home. We cannot tell you how important that was for us while we were away from home, a bit anxious, and doing treatments. We cannot thank you enough, but want to give you a token of our appreciation.
Since we have left there he (our son) has been asking to go potty a little more often. Not yet really potty trained, it is a step in the right direction. He has been walking around the house saying "Monkey Boy" (his nickname we gave him). He also happens to repeat something Mommy said! lol. I had stepped on a pricker for the grass, and I happened to say "son of a b**ch" and he repeated it! I couldn’t help but laugh. He hasn’t said it since so that’s a plus. Other than that, the teachers have said that he is starting to focus more and it is easier to get him back to focus when coming out of a meltdown. He seems to reply sometimes with the right answer when asked a question like "Do you got it?" he replies; "I got it", as he walks away. He has been doing really good. I am in hopes to see more improvements and also would like to come back when we can.
Last Fall 2013 as a paraplegic, I had the privilege of experiencing and witnessing myself how this treatment can save and improve lives. This great news in medicine must be shared and allowed to grow. The approach is somewhat basic in nature, but with technological inventions it becomes a common tool to one day be utilized for everyone. This therapy is definitely part of our future preventative and post healthcare. The staff are another proof of this with alert professionals providing a comfortable atmosphere and an enormous caring spirit. They really took time to explain how it works. I think they really like that part. The story for me is, after an exhausting failure with old western medicine techniques, my pressure sore injury was not improving. So after web surfing a bit I came across Hyperbaric Centers of Florida. My familiarity was limited to how it helped divers who had been injured or just need to decompress. The first 10 visits were really informative and eye opening. To say detoxifying is part of the process is a polite way of saying your going to be surprised that was in you. But that’s great! You’re on your way to a healthier you! The next 10 days started showing better circulation in my legs, more energy, sleeping better and improvement in general all around. My last 10 days, making it 30 straight treatments, I wanted to go to see if I could benefit anymore. I believe it did. And whenever I need a 10-day cleansing and revitalizer, you can bet I’m going to Hyperbaric Centers of Florida!
NOEL – Wound Care Treatment
Wound Care Treatment
It is just a month since the end of our 20-day session you afforded us. Hilda’s short-term memory is much improved. Also, her skin tone and color is better. Old age brings on numerous bruises and we find them healing more quickly. Hilda’s energy level is also up a few points. I had no specific complaints, so I was there to assist Hilda and be a companion in the chamber. I found the overall experience to be a pleasant one. It was also a pleasure to meet persons who are having positive results from the sessions.
TRENT FAMILY – Short Term Memory – General Health
Short Term Memory - General Health
Hi Stephanie, We appreciate the kindness, care and support that you all showed to us during Christian's treatments. Everyone was so nice and very helpful to our family. We are pleased that Christian is now able to communicate with speech, everyday he is getting more clear and confident. At night when it's time to go to bed he feels really great about practicing saying all of his new words for hours. Christian can say; " I am happy, I feel good."
His face looks totally different now that he knows he can get his words out, he is getting better at speaking everyday. One of his teacher's today was saying how she just let him talk to her all day.
This teacher has just recently returned to school, she had been out since summer due to having a surgery. Mrs. Lisa told us today that she is amazed to see the difference in Christian and to now be able to know what he is thinking. We are all excited to hear something new from him everyday.
Update:
I got another good report from school today, this time from Christian's main teacher. She wanted to tell me herself that he talked to her all day. That was very exciting for her! I could see how surprised she was because he was still talking as she was talking to me.
Tammy – Autism Treatment
Autism Treatment
Joseph (my son) is showing more eye contact, more affection and more conversation. His OCD has lessened (repetitions are not as constant). It has not been 3 weeks yet, but I do see improvement. Thanks to Stephanie, Miss Carol, Fred and Barbara for taking care of him. He still remembers the M & M rewards.
Marta – Autism Treatment
Autism Treatment
The Guerra family is very thankful for your services at Hyperbaric Centers of Florida. Our experience in your facility was very pleasant, clean and home warming. The treatment has been a blessing to our son Kenny. He has been recovering and progressing amazingly, we’ve noticed many changes after his treatments. His personality, thinking, reasoning are coming back like Kenny was always. He is more independent, he’s cooking his own meals, playing video games, taking care of his image, he saves, showers on his own and amazingly all his acne has disappeared. Wish you our best wishes.
Traumatic Brain Injury Treatment
My experience in the Hyperbaric Centers of Florida was an easy and pleasant time. Very friendly professional staff. The office hours were great, because it was really conducive for my schedule.
Cherie Alvis – Anti-Aging Treatment
Anti-Aging Treatment
I have relied on the experts that are opening Hyperbaric Centers of Florida to provide treatment for my Lyme Disease for the past five years.
Mary, Colorado Springs – Lyme Disease Treatment
Lyme Disease Treatment
Our Experience at your facility was much more than we expected! Everyone was very professional and friendly, helpful, knowledgeable and patient. Regan, we believed, truly enjoyed her time in the chamber. Not one time did she complain about her visits and in fact, she was very eager to go!
Since her therapy has stopped, our family and friends agree that they see development in Regan. She tends to make more eye contact with strangers, asks intriguing questions for clarification and initiates spontaneous conversation with others. We are very pleased with everything and look forward to future hyperbaric opportunities.
Becky – Autism Treatment
Autism Treatment
Everyone at the center was kind, professional and supportive during duration of treatments. Richard has better energy levels, better at performing work tasks, and reading with better comprehension. He seems to have improved communication skills as well as helping him with his friendships. Thank you again for your kindness and support.
Lynn – Neurological Damage Treatment
Neurological Damage Treatment
Larry and I are feeling fine…. But especially Larry! He is able to hop up in the back of his pickup truck in one leap! Last year before treatment he could hardly make it with at stool! We are leaving soon, but plan on a few more Hyperbaric Oxygen Therpay in the fall to keep the good health momentum going forward.
Buckland Family – Neuropathy & Planter Fasciitis
Neuropathy & Planter Fasciitis Treatment
Six years ago I was given four months to live as a result of liver failure. The owners of Hyperbaric Centers of Florida provided treatment for me at their center in Texas and I was able to begin to grow new liver tissue. My primary care physician can not believe that his four month prediction was incorrect. I do require "booster therapy" which involves a few treatments every 6 to 8 months, but my health is excellent and I look forward to a long and productive life.
Debbie, Oklahoma City – Liver Failure Treatment
Liver Failure Treatment
We are hoping that we will be able to do treatment with you guys every summer!!!
HEDGES FAMILY – Autism and Lyme Disease Treatment
Autism and Lyme Disease Treatment
We miss all of you there, too. Maybe we'll get back to you some day. You made us feel very comfortable. I feel a lot better already, and can't wait to get back bowling. I start today. Wish me luck. Regards to all and GOD BLESS YOU.
Jimmy V. Calcagno – General Wellness Therapy
General Wellness Therapy
